Key Achievements
  • Published Estrous phase dataset on Dryad digital repository (link below)
  • Presented findings on early stages of project at SYNAPSE alongside lightning talk
  • Leveraged model interpretability to uncover more about the impact of hormones at the single cell level
Python Machine Learning Signal Processing Data Analysis
01

Meitzen Lab - NC State

Jan. 2024 - Present

Using single-cell neuron recordings to classify animals across phases of the estrous cycle, a study of both ML model and single cell interpretability.

Key Achievements
  • Conducted extensive research into optimal use of high-powered computing resources for reinforcement learning training
  • Wrote several RL environments, comparing efficiency of computationally intensive tasks
  • Researched optimal reward function configurations for several RL policies
Reinforcement Learning EMG Analysis Gymnasium Prosthetics
02

Neuro Rehabilitation Engineering Lab (NREL)

Aug. 2024 - Present

Working on reinforcement learning decoding applications for EMG-based upper-limb prosthetics.

Key Achievements
  • Designed functional concepts of modification at 50 micron scale
  • Researched manufacturing capabilities for small scale modifications
  • Studied medical device/ regulatory development lifecycle
Medical Devices CAD Regulatory Affairs Neurosurgery
03

CINT Fellowship - WashU

May 2024 - Aug. 2024

Prototyped modifications to stereotactic depth electrodes for enhanced diagnostic fidelity in epilepsy patients.

Key Achievements
  • Developed data processing pipelines for HRI experiments
  • Conducted literature reviews optimal learning conditions
  • Presented findings on autonomy and trust in robotics
  • Conducted manual QAing of surveys from various experiments
Python Data Processing Literature Review R
04

LACELab - NC State

Aug. 2023 - Dec. 2023

First research experience in undergrad, assisting in projects dealing with optimal learning conditions and trust in human-robot interaction.

Selected Projects

Estrous Phase Classification Project

Meitzen Lab Research Project

NC State University

Taking the dataset I published in the mEPSC Dataset Project, I utilized various Python packages to import the data into google colab, make it useable, and filter it. A variety of biological signal types (spiking, mEPSC, and passive membrane potential) each of which capture different aspects of neuronal function were explored. I then tested the model accuracies of various machine learning algorithms across features extracted from the different signal types, indicating which signal type encodes the state of estrous cycle phase best. This more broadly represents an exploration of how best to computationally represent small scale neuromodulatory differences in cells within the brain.

On the right is a picture of my poster presentation at SYNAPSE 2025, alongside this, I was selected to give a lightning talk which you can listen to using the link below.

Watch Presentation →
Estrous Phase Classification Poster
Meitzen Lab

mEPSC Dataset Publication

Meitzen Lab Research Project

Dryad Digital Repository

As part of my first project in the Meitzen lab I used a simple Python script to automate the merging of many excel spreadsheets into a dataset with data from two papers which I manually cleaned. I gained a lot of knowledge about how to read academic papers and understand what is important amongst a lot of jargon during this time.


Proaño, Stephanie B.; Krentzel, Amanda; Morris, Hannah J.; Kunz, Lindsey M.; Dorris, David M.; Raina, Armaan; Meitzen, John. (2024). Medium spiny neuron electrophysiological properties across male rats and female rats in different estrous cycle phases in the nucleus accumbens core: Excitatory synaptic input, action potential, and intrinsic properties [Dataset]. Dryad. https://doi.org/10.5061/dryad.k0p2ngfgm


On the left is a picture of me working on the computer in the patch-clamp rig room in the lab. It's pretty crazy to think that we can poke singular neurons and figure out what they are up to.

Innovation in Neurotech Fellowship

Center for Innovation in Neuroscience and Technology Washington University in St. Louis Medical School

Department of Neurosurgery

During my time with the Center for Innovation in Neuroscience and Technology (CINT) another undergraduate student and I drafted and prototyped substantial modifications to stereotactic depth electrodes to enhance their functionality while retaining their core purpose under Dr. Eric Leuthardt. I learned so much about FDA regulations/ pathways for medical devices, the differences in how neurosurgeons and engineers communicate, and the importance of observing before you build. I had the exciting opportunity to watch neurosurgery, work with very fancy 3D printers, and speak with experts from so many different domains.

Washington University